Genetic evidence of PTPN22 effects on chronic lymphocytic leukemia
نویسندگان
چکیده
منابع مشابه
Genetic evidence of PTPN22 effects on chronic lymphocytic leukemia--author's response to Hebbring.
The recent article by Negro et al represents a thorough investigation into the effect of Lyp, the gene product of PTPN22, on BCR signaling in the pathogenesis and progression of chronic lymphocytic leukemia (CLL).1 This study shows that increased Lyp enhances Akt, a serine/threonine kinase involved in cell survival and tumorigenesis, despite a negative effect on proximal BCR signaling molecules...
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ژورنال
عنوان ژورنال: Blood
سال: 2013
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2012-08-450221